Benzylidene derivatives

Details Benzylidene derivatives Benzylidene derivatives

A - Human Necessities

61

K

260/552, 260/515

A61K 31/215 (2006.01) A61K 31/05 (2006.01) A61K 31/13 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/20 (2006.01) A61K 31/21 (2006.01)

Patent

CA 1072112

ABSTRACT Compounds of the formula: Image (I) in which X1, X2 and X3, which are identical or different, each represent hydrogen, halogen, methyl, or methoxy, n represents an integer from 1 to 10, and R represents hydroxyl, OM, NH2, NH(CH2)3-COOH, NH(CH2)3-COOM, (where M represents an alkali metal atom), NH(CH2)3-COOC2N5, NH-cycloalkyl, NH-phenyl, NH-benzyl (where the benzyl radical is unsubstitued or substituted by halogen or trifluorooethyl), NH-alkyl, N(alkyl)2 and N-(alkyl)-(benzyl), the aforesaid alkyls being straight or branched and having from 1 to 4 carbon atoms and the aforesaid cycloalkyls having from 3 to 6 carbon atoms, except that when X1 and X3 are both hydrogen, n is 1 and R is OH, X2 is not chlorine in the 5-position are useful in the treatment of epilepsy by oral or parenteral administration.

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