Benzylidene derivatives

Details Benzylidene derivatives Benzylidene derivatives

C - Chemistry, Metallurgy

07

D

C07D 275/02 (2006.01) A61K 31/38 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/54 (2006.01) C07D 279/02 (2006.01) C07D 291/02 (2006.01) C07D 291/06 (2006.01) C07D 331/04 (2006.01) C07D 333/48 (2006.01) C07D 409/02 (2006.01) C07D 417/02 (2006.01) C07D 417/10 (2006.01) C07D 419/02 (2006.01)

Patent

CA 2109498

-1- Abstract The present invention is directed to benzylidene derivatives having anti-inflammatory activities, as shown in the following formula I: Image I wherein A is -CH2- or -CH2CH2-; B is a bond or -CH2-, -CHOH-, -CO-, -O-, or A and B taken together may form -CH=CH-; D is >N- or >CH-; R1 and R2 each independently represent hydrogen, lower alkyl or lower alkoxy; R3 is hydrogen, lower alkyl, cycloalkyl, lower alkoxy, arylalkyloxy, heteroarylalkyloxy, lower alkylcarbonyl, arylcarbonyl, substituted or unsubstituted carbamoyl, or a group of the formula: Image wherein R4 is hydrogen, hydroxy, substituted or unsubstituted amino, aryl, heteroaryl, hydroxycarbonyl or lower alkyloxycarbonyl; n is an integer of 0 - 3.

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