Benzylidene-thiazolidinediones and analogues and their use...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/34 (2006.01) A61K 31/4166 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) C07D 233/40 (2006.01) C07D 233/42 (2006.01) C07D 233/96 (2006.01) C07D 261/12 (2006.01) C07D 277/20 (2006.01) C07D 277/36 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2383347

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

L'invention se rapporte à certains hétérocycles substitués correspondant à la formule (I) qui sont utiles dans le traitement de maladies relatives au métabolisme des lipides et des glucides telles le diabète de type 2, la différentiation d'adipocytes, la prolifération non contrôlée tel que le lymphome, la maladie de Hodgkin, la leucémie, le cancer du sein, le cancer de la prostate ou les cancers en général, ainsi que des syndromes inflammatoires tels que l'ostéoarthrite, l'arthrite rhumatoïde, l'iléite régionale ou l'affection intestinale inflammatoire.

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