C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/471, 260/474
C07C 119/06 (1980.01) C07C 148/00 (1980.01) C07C 153/07 (1980.01)
Patent
CA 1120946
ABSTRACT OF THE DISCLOSURE The invention relates to a compound having anti- inflammatory activity characterized by having the formula: Image where R is hydrogen or alkyl; X1 and Y1 may be the same or different and are hydrogen, alkyl, cyano, nitro, amino, halo- loweralkoxy, haloloweralkyl, halo, acyl, acyloxy, thio, acyl- thio, loweralkylthio, loweralkylsulflnyl, and loweralkyl- sulfonyl; X and Y are the same or different and are hydrogen, alkyl, halo, cyano, nitro, loweralkylthio, carboxy, carbalkoxy, loweralkylsulfinyl, and loweralkylsulfonyl; R8 may also be hydrogen, carboxy. cyano, nitro. loweralkylsulfonyl, carb- alkoxy, cycloalkyl, cycloalkenyl, aryl and heteroloweralkyl- idenyl, and with the proviso that at least two of R8, X, X1, Y and Y1 are other than hydrogen, and when both X1 and Y1 are halo, X and Y are not halo, and further when R8 is cyano, X1 and Y1 are other than alkyl.
316173
Douglas George H.
Nuss George W.
Santora Norman J.
Goudreau Gage & Associates
Rorer (william H.) Inc.
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