C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2157037
Compound of formula (I) wherein A, together with the carbon to which it is at- tached, forms a C3 to C7 car- bocylic or C7 to C11 carbobi- cyclic group, each of which can be saturated or unsatu- rated, optionally mono-, di- or trisubstituted with a sub- stituent or substituents inde- pendently selected from C1 to C6 alkyl, C1 to C6 alkenyl and halo; M is a single bond or C1 to C5 alkyl; Q is phenyl or phenyl mono- or disubstituted with a substituent or substituents independently selected from halo, hydroxy, C1 to C4 alkyl and C1 to C4 hydroxyalkyl; R1 is -CO2H, -PO3H, -SO3H, -NHSO2CF3, -CONHSO2(C6H5), -CONHSO2CF3 or tetrazolyl; R2 is C2 to C8 alkyl, C3 to C8 cycloalkyl or -(CH2)n-S-(CH2)nCH3; each n is independently an integer from 0 to 4; one of W, X, Y and Z is N; three of W, X, Y and Z are CR3 and each R3 is independently hydrogen, halo, C1 to C5 alkyl or CO2H, inhibit angiotensin II in mammals and are useful in treating conditions such as hypertension, congestive heart failure and glaucoma and as the active ingredient in pharmaceutical compositions for treating such conditions.
Carpino Philip A.
Da Silva Jardine Paul A.
Wester Ronald T.
Pfizer Inc.
Smart & Biggar
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