Benzylphosphonic acid tyrosine kinase inhibitors

Details Benzylphosphonic acid tyrosine kinase inhibitors Benzylphosphonic acid tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/553 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2078214

Benzylphosphonic acid compounds of the formula: Image (I) (wherein A is a lipophilic group which is neither strongly basic nor strongly acidic, such as phenyl, benzol, Image , Image , Image , Image , Image Image , or and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).

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