Benzylpiperidine derivatives

Details Benzylpiperidine derivatives Benzylpiperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/395 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 419/06 (2006.01)

Patent

CA 2161618

Benzylpiperidine derivatives of the formula I Image (I) in which R1 is H, Hal or nitro R2 is a benzyl group, which is unsubstituted or substituted by Hal on the aromatic, in the 2- , 3- or 4-position of the piperidine ring, with the proviso that R2 ? 4-benzyl if X is -CO-, Y and Z are -CH2- and R1 is H, R3 is H or A, X is -CO- or -SO2-, Y is -CH2-, -NH-,, -O-, -S-, or alternatively -CO- if X is -CO-, and Z is -NH- or -NA-, Z is -CH2-, -C(A)2-, -CH2CH2-, -CH=CH-, -CO-, -NH-, -NA-, -O- or a bond, where one of the radicals X, Y and Z can be -O-, -S- or -NH-, but X-Y or Y-Z respectively is not -O-O-, -S-S-, -NH-O-, -O-NH, -NH-NH-, -O-S- or -S-O-, A is alkyl having 1 - 6 C atoms, B is O, H + OH, Hal is F, Cl, Br or I and n is 0, 1 or 2 and their salts show a high affinity for binding sites of amino acid receptors and are suitable for the treat- ment of neurodegenerative disorders.

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