Benzylpyrimidines

Details Benzylpyrimidines Benzylpyrimidines

C - Chemistry, Metallurgy

07

D

260/151, 260/262

C07D 239/48 (2006.01) C07D 207/32 (2006.01) C07D 207/325 (2006.01) C07D 207/327 (2006.01) C07D 295/155 (2006.01)

Patent

CA 1037476

ABSTRACT Novel benzylpyrimidine derivatives of the general formula Image wherein R1 and R2 each independently represent a C1-3 alkyl, C1-3 alkoxy, C2-3 alkenyl or C2-3 s alkenyloxy group, Z represents a nitro, amino, pyrrolo, pyrrolidino, piperidino, NHR4, -N(R4)2, -NHR5, -N(R4)(R5), -NR4COOR4, -NHCOOR4, -NHCONHR3, -NHCSNHR3, -N3, -N=N-N(R4)2, -N(NO)R4, or -NR3-NH2 group, R4 represents a C1-3 alkyl or C2-3 alkenyl group, R5 represents an acyl group, R3 represents a hydrogen atom or a C1-3 alkyl or C2-3 alkenyl group, A represents an oxygen atom bonded to one of the cyclic nitrogen atoms and n stands for zero or 1, and salts thereof are prepared by various methods. The novel compounds possess antibacterial activity and potentiate antibacterially-active sulphonamides.

207509

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