.beta.(1-3)-glucan diagnostic assays

Details .beta.(1-3)-glucan diagnostic assays .beta.(1-3)-glucan diagnostic assays

G - Physics

01

N

G01N 33/566 (2006.01) C07K 16/18 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2314342

Methods of isolating .beta.(1-3)-glucan or .beta.(1-3)-glucan-containing organisms in a sample, or of detecting the presence of .beta.(1-3)-glucan or .beta.(1-3)-glucan-containing organisms in a sample, utilizing binding agents for .beta.(1-3)-glucan, such as LacCer, GalCer, globotriaosylceramide and asialoganglioside-GM1, are described. Methods of diagnosing fungal infection, by detecting .beta.(1-3)-glucan or .beta.(1-3)-glucan-containing organisms, are also described. Antibodies and kits useful in the methods are also disclosed.

L'invention concerne des procédés d'isolement du .beta.(1-3)-glucan ou d'organismes contenant du .beta.(1-3)-glucan dans un échantillon, ou de détection de la présence du .beta.(1-3)-glucan ou d'organismes contenant du .beta.-(1-3)-glucan dans un échantillon, au moyen d'agents de liaison pour le .beta.(1-3)-glucan, tel que LacCer, GalCer, globotriaosylcéramide et d'asialoganglioside-GM1. Elle porte aussi sur des méthodes diagnostiques de l'infection fongique, qui consistent à détecter le .beta.(1-3)-glucan ou des organismes contenant du .beta.(1-3)-glucan. Des anticorps et des kits utiles dans les procédés sont également décrits.

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