.beta.1,3-n-acetyl-d-galactosaminyltransferase protein and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2517469

An N-acetyl-D-galactosamine transferase protein characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine via a .beta.1,3-bond. It preferably has an amino sequence represented by SEQ ID NO:2 or 4. A method of examining canceration by using a nucleic acid for assaying which is hybridizable under stringent conditions with a base sequence represented by SEQ ID NO:1 or 3 or a base sequence being complementary to at least one of these base sequences.

L'invention concerne une protéine de N-acétyl-D-galactosamine transférase caractérisée en ce qu'elle résulte d'une conversion de N-acétyl-D-galactosamine en N-acétyl-D-glucosamine au moyen d'une liaison .beta.1,3. Cette protéine comprend de préférence une séquence d'acides aminés représentée par SEQ ID NO :2 ou 4. L'invention concerne également un procédé d'analyse de cancérisation consistant à utiliser des acides nucléiques afin de détecter lequel peut être hybridé dans des conditions stringentes avec une séquence de bases représentée par SEQ ID NO :2 ou 3, ou avec une séquence de bases complémentaire à au moins une de ces séquences de bases.

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