.beta.-alanine derivatives

Details .beta.-alanine derivatives .beta.-alanine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61P 9/00 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2371824

The invention relates to novel .beta.-alanine derivatives of general formula (I), wherein Q1, Q2, Q3. Q4, R1, R2, R3, R4, R5, R6 and n have the meaning cited in patent claim 1 and to their physiologically acceptable salts or solvates. Said substances are integrin inhibitors and can be used in the treatment of thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections and restenosis after angioplasty or in pathological processes induced or propagated by angiogenesis.

Des dérivés de la beta -alanine de formule générale (I), dans laquelle Q1, Q2, Q3, Q4, R<1>, R<2>, R<3>, R<4>, R<5>, R<6> et n ont la signification donnée dans la revendication 1, ainsi que leurs sels et solvates physiologiquement tolérés, sont des inhibiteurs d'intégrine et peuvent être utilisés pour le traitement des thromboses, de l'infarctus, des maladies cardiaques coronariennes, de l'athérosclérose, des inflammations, des tumeurs, de l'ostéoporose, des infections et de la resténose, après une angioplastie ou lors de manifestations pathologiques entretenues ou propagées par angiogénèse.

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