Beta-amino acid derivatives as inhibitors of matrix...

Details Beta-amino acid derivatives as inhibitors of matrix... Beta-amino acid derivatives as inhibitors of matrix...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4545 (2006.01) A61P 29/00 (2006.01) C07D 211/34 (2006.01) C07D 211/58 (2006.01) C07D 215/14 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2400168

The present application describes novel .beta.-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3, R4, and R4a are defined in the present specification, which are useful as metalloprotease and as TNF-.alpha. inhibitors.

La présente demande décrit de nouveaux dérivés de .beta.-aminoacides ou des formes de sel ou bien de promédicaments pharmaceutiquement acceptables de ceux-ci, formule dans laquelle A, X, Z, U?a¿, X?a¿, Y?a¿, Z?a¿, R?1¿, R?2¿, R?3¿, R?4¿ et R?4a¿ sont définis dans la présente description, lesquels sont utiles en tant qu'inhibiteurs de métalloprotéase et du TNF-.alpha..

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