C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/44 (2006.01) A61K 31/277 (2006.01) A61K 31/343 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) C07C 255/29 (2006.01) C07C 271/24 (2006.01) C07C 311/13 (2006.01) C07C 311/20 (2006.01) C07C 311/46 (2006.01) C07D 307/85 (2006.01) C07D 317/60 (2006.01) C07D 333/32 (2006.01)
Patent
CA 2410303
The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cysteine proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
La présente invention concerne des composés représentés par la formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ et n sont tels que définis dans la description et les revendications, ainsi que certains de leurs sels et esters pharmaceutiquement admis. Ces composés conviennent au traitement d'affections associées au métabolisme des protéases de la cystéine (ostéoporose, ostéoarthrite, arthrite rhumatoïde, métastase tumorale, glomérulonéphrite, athérosclérose, infarctus du myocarde, angine de poitrine éventuellement instable, crises, rupture de plaque, attaque cérébrale ischémique, amaurose fugace, occlusion artérielle périphérique, resténose après angioplastie et pose de stent, anévrisme aortique abdominal, affections autoimmunes, malaria, cytopathie rétinienne, affections respiratoires).
Gabriel Tobias
Pech Michael
Rodriguez Sarmiento Rosa Maria
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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