C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/08 (2006.01) A61K 31/551 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2502269
The present invention is directed to compounds of formula I: (see formula I) which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.
La présente invention concerne des composés qui sont inhibiteurs de l'enzyme dipeptidylpeptidase IV ("inhibiteur DP-IV") et qui sont utiles dans le traitement ou la prévention de maladies dans laquelle l'enzyme dipeptidylpeptidase-IV est impliquée, par exemple, les diabètes et notamment les diabètes de type 2. L'invention concerne également des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de ces maladies dans lesquelles l'enzyme dipeptidylpeptidase-IV est impliquée.
Biftu Tesfaye
Feng Danqing Dennis
Liang Gui-Bai
Qian Xiaoxia
Weber Ann E.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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