C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2450740
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
L'invention a trait à des composés inhibiteurs de la dipeptidyl peptidase IV ("inhibiteurs DP-IV ") qui sont utiles dans le traitement ou dans la prévention des maladies dans lesquelles est impliquée dipeptidyl peptidase IV, telles que le diabète et notamment le diabète de type 2. L'invention a également trait à des compositions pharmaceutiques comprenant ces composés et à l'utilisation de ces composés et compositions dans la prévention ou dans le traitement de ces maladies dans lesquelles dipeptidyl peptidase IV est impliquée.
Edmondson Scott D.
Fisher Michael H.
Kim Dooseop
Maccoss Malcolm
Parmee Emma R.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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