Beta-amyloid binding factors and inhibitors thereof

Details Beta-amyloid binding factors and inhibitors thereof Beta-amyloid binding factors and inhibitors thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/353 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/515 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2469690

The present invention relates to a VEGF polypeptide that binds to beta- amyloid. The present invention also relates to a compound that sequesters beta- amyloid. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to beta-amyloid, and thus relates to diagnosis and treatment of Alzheimer's Disease.

L'invention concerne un polypeptide VEGF se liant à la béta-amyloïde. L'invention concerne également un composé séquestrant la béta-amyloïde, ainsi qu'un composé séquestrant VEGF. Par conséquent, l'invention concerne aussi un procédé de balayage d'un composé inhibant la liaison de VEGF à la béta-amyloïde et des diagnostic et traitement de la maladie d'Alzheimer.

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