Beta-amyloid inhibitors and use thereof

Details Beta-amyloid inhibitors and use thereof Beta-amyloid inhibitors and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2522460

Peptides and derivatives or analogs thereof are provided for having .beta.- amyloid aggregation inhibitory activity, useful in the treatment and prevention of diseases such as Alzheimer~s disease, Dementia pugilistica (including head trauma), Hereditary Cerebral Haemorrhage with amyloidosis of the Dutch type (HCHWA-D) and vascular dementia with amyloid angiopathy.

La présente invention a trait à des peptides et des dérivés ou des analogues de ceux-ci présentant une activité inhibitrice d'agrégation de .beta.-amyloïdes, utiles dans le traitement et la prévention de maladies telles que la maladie d'Alzheimer, la démence pugilistique (y compris le traumatisme crânien), l'hémorragie cérébrale héréditaire à amylose de type hollandais (HCHWA-D) et la démence vasculaire à angiopathie amyloïde.

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