C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/02 (2006.01) A61K 31/472 (2006.01) A61P 27/06 (2006.01) C07D 217/24 (2006.01) C07D 333/24 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2731869
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
La présente invention concerne des composés amidés béta et gamma-amino isoquinoline et des composés benzamide substitué. En particulier, l'invention concerne des composés qui affectent la fonction des kinases dans une cellule et sont utiles en tant qu'agents thérapeutiques ou avec des agents thérapeutiques. Les composés de l'invention sont utiles dans le traitement d'une variété de maladies et d'états, y compris les maladies de l'il telles que le glaucome, les maladies cardiovasculaires, et les maladies caractérisées par une croissance anormale, telles que le cancer. L'invention concerne en outre des compositions contenant les composés amidés béta ou gamma-amino isoquinoline ou des composés benzamide substitué.
Delong Mitchell A.
Royalty Susan M.
Sturdivant Jill Marie
Aerie Pharmaceuticals Inc.
Ledgley Law
LandOfFree
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