.beta.-carbolines, their preparation and use as medicinal...

Details .beta.-carbolines, their preparation and use as medicinal... .beta.-carbolines, their preparation and use as medicinal...

C - Chemistry, Metallurgy

07

D

167/211, 260/276

C07D 471/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 1240324

ABSTRACT .beta. -carboline derivatives of general Formula I Image (I) wherein R3 is Image -COOR6 or Image , wherein R5 is C1-5 alkyl, R6 is lower alkyl, aralkyl, or alkoxyalkyl of up to 7 carbon atoms, and R7 and R8 are hydrogen C1-5 alkyl, or, collectively with the amido nitrogen atom, piperidino, R4 is hydrogen, C1-3 alkyl, or CH2OR9 wherein R9 is C1- 3 alkyl, atoms, and RA is -COOR10 Image , wherein R10 is hydrogen, lower alkyl, alkoxyalkyl or alkenyl of up to 5 carbon atoms, or benzyl, or X is oxygen or sulfur, and R11 and R12 each are hydrogen, lower alkyl or alkenyl or, collectively with the amido nitrogen atom, represent a hetero ring, are prepared by conventional methods and exhibit, inter alia, an effect on the central nervous system and are suitable for use as psychopharmaceuticals.

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