C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) C07D 265/30 (2006.01)
Patent
CA 2521300
This invention provides beta-carboline compounds of formula (I) wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2 mediated diseases such as inflammatory diseases and cancer.
L'invention concerne des composés bêta-carbolines représentés par la formule (I), dans laquelle le noyau A est un noyau pyridinyle, pyrimidinyle, morpholinyle, pipéridinyle, pipérazinyle, pyrrolidinyle, pyranyle, tétrahydrofuranyle, cyclohexyle, cyclopentyle ou thiomorpholinyle substitué, et R?1¿, R?2¿ et R?3¿ sont tels que définis dans la description. Ces composés sont des inhibiteurs d'IKK-2 utiles pour traiter des maladies médiées par IKK-2, telles que les maladies inflammatoires et le cancer.
Castro Alfredo
Fleming Paul E.
Hepperle Michael E.
Little Jeremy D.
Liu Julie Fields
Gowling Lafleur Henderson Llp
Millennium Pharmaceuticals Inc.
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