Beta cell antigen

Details Beta cell antigen Beta cell antigen

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082162

2082162 9117186 PCTABS00008 Beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells located in pancreatic islets of Langerhans, which protein contains an epitope recognised by T-cell clone 1C6. The antigen has a molecular weight of 38 kD. The variable part of the .beta.-chain of the T-cell receptor of clone 1C6 belongs to the TCR-V.beta.19 family. Peptide which mimicks said beta cell antigen epitope and can be recognised by T-cell clone 1C6. T-cell which is capable of recognising the beta-cell antigen, receptor of this T-cell, and peptide mimicking this T-cell receptor. Antibody specific for a T-cell which is capable of recognising the beta cell antigen, and antibody specific for the beta cell antigen. Use of one of these substances for type-1 diabetes mellitus diagnostics, monitoring, therapy or prevention.

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