Beta disubstituted metalloprotease inhibitors

Details Beta disubstituted metalloprotease inhibitors Beta disubstituted metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/70 (2006.01) A61K 31/18 (2006.01) A61K 31/505 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07C 323/59 (2006.01) C07D 213/32 (2006.01) C07D 213/76 (2006.01) C07D 233/80 (2006.01) C07D 233/84 (2006.01) C07D 233/86 (2006.01) C07D 239/22 (2006.01) C07D 239/38 (2006.01) C07D 249/12 (2006.01) C07D 263/32 (2006.01) C07D 263/46 (2006.01) C07D 277/36 (2006.01) C07D 333/18 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 47

Patent

CA 2386485

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R1, R2, R3, R4, R5, R6, G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

La présente invention concerne des composés qui sont des inhibiteurs de métalloprotéases et qui conviennent pour le traitement de pathologies caractérisées par une suracitivité de ces enzymes. Plus particulièrement, ces composés comportent une structure représentée par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, G et Z sont tels que présentés dans le descriptif de l'invention. Cette invention concerne également des isomères, diastereomères et énantiomères optiques de formule (I), ainsi que leurs sels, amides biohydrolysables, esters et imides acceptables au plan pharmaceutique. L'invention porte également sur des compositions pharmaceutiques qui renferment ces composés et sur des méthodes de traitement de maladies en rapport avec des métalloprotéases au moyen des composés ou compositions pharmaceutiques susmentionnés.

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