.beta.-galactoside - .alpha. 2,6-sialyltransferase gene

Details .beta.-galactoside - .alpha. 2,6-sialyltransferase gene .beta.-galactoside - .alpha. 2,6-sialyltransferase gene

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2252493

A novel gene encoding a protein having the .beta.-galactoside .alpha.-2,6- sialyltransferase activity. This gene has the amino acid sequence represented by SEQ ID NO:1 optionally undergoing the deletion, substitution or addition of one or more amino acids and encodes the protein with the .beta.-galactoside .alpha.-2,6-sialyltransferase activity. The invention further provides expression vectors for the .beta.-galactoside .alpha.-2,6-sialyltransferase protein with the use of the above gene and host cells and recombinant proteins thereof. The amino acid sequence of the enzyme encoded by the above gene is not homologous with that of the conventionally known sialyltransferases. Moreover, the membrane-binding region thereof is located at the C-end differing from those of the conventionally known enzymes.

Nouveau gène codant une protéine ayant l'activité de la beta -galactosidase alpha -2,6-sialyltransférase. Ce gène comprend la séquence d'acides aminés représentée par SEQ ID NO:1, soumise éventuellement la délétion, la substitution ou l'addition d'un ou plusieurs acides aminés et code la protéine ayant l'activité de la beta -galactoside alpha -2,6-sialyltransférase. L'invention se rapporte encore à des vecteurs d'expression pour la protéine beta -galactoside alpha -2,6-sialyltransférase au moyen du gène de l'invention et à des cellules hôtes et des protéines de recombinaison de celle-ci. La séquence d'acides aminés de l'enzyme codée par ledit gène n'est pas homologue à celle des sialyltransférases classiques. De plus, la région de fixation à la membrane de celle-ci se situe au niveau du terminal à la différence de celle des enzymes connues classiques.

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