C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/38 (2006.01) A61K 31/4164 (2006.01) A61K 31/4174 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/52 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 233/84 (2006.01) C07D 233/90 (2006.01) C07D 235/28 (2006.01) C07D 249/12 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2452039
The invention relates to substituted alcohol compounds of the formula (I), wherein X, R1, R2, R3, RN, R20 et RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzhaimer's sufferers.
L'invention concerne des composés d'alcools substitués représentés par la formule (I), dans lesquels X, R¿1?, R¿2?, R¿3?, R¿N?, R¿20? et R¿C? ont la signification indiquée dans la description. Lesdits composés sont utiles dans le traitement ou la prévention de la maladie d'Alzheimer et plus particulièrement pour des composés capables d'inhiber la bêta-sécrétase, une enzyme qui clive la protéine précurseur de la protéine amyloïde afin que le peptide bêta-amyloïde (A-bêta) soit produit, ce dernier étant un composant majeur des plaques amyloïdes qui se trouvent dans le cerveau des sujets atteints de la maladie d'Alzheimer.
Hom Roy
John Varghese
Tucker John
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company Llc
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