C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/299
C07D 498/04 (2006.01) A61K 31/42 (2006.01) C07D 503/00 (2006.01)
Patent
CA 1102810
ABSTRACT .beta.-Lactam antibacterial agents of the formula (II): Image (II) or an ester thereof wherein R1 is a hydrogen atom, an alkyl group of up to 5 carbon atoms, a cycloalkyl group of 5 or 6 carbon atoms, a hydroxyalkyl group of up to 5 carbon atoms or a moiety of sub-formula (a): Image (a) wherein R2 is a hydrogen, fluorine, chlorine or bromine atom or an alkyl group of 1-3 carbon atoms, an alkoxyl group of 1-3 carbon atoms, an acyloxyl group of 1-3 carbon atoms, a hydroxyl group, an alkoxycarbonyl group containing 1-3 carbon atoms in the alkoxy part, or a group -N(R5)CO.R6, -N(R5)SO2R6 or -CO-NR5R6 where R5 is a hydrogen atom or an alkyl group of 1-3 carbon atoms or a phenyl or benzyl group and R6 is an alkyl group of 1-3 carbon atoms or a phenyl or benzyl group; R3 is a hydrogen, fluorine or chlorine atom or an alkyl group of 1-3 carbon atoms, an alkoxyl group of 1-3 carbon atoms or an acyloxyl group of 1-3 carbon atoms; and R4 is a hydrogen fluorine or chlorine atom or an alkyl group of 1-3 carbon atoms or an alkoxyl group of 1-3 carbon atoms. Processes for preparing the compounds are also described.
301662
Clarke Brian P.
Stirling Irene
Beecham Group Limited
Borden Ladner Gervais Llp
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