.beta.-lactam antibiotic-containing tablet and production...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/545 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/546 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2248179

This invention provides .beta.-lactam antibiotic-containing tablets capable of being orally taken either as such owing to their being small-sized, hence still easily swallowable, or, in the case of administration to the aged encountering some difficulty in swallowing, in the form of dispersions resulting from easy self-disintegration upon being dropped into water in a glass as well as a method of producing the same. The tablets of this invention comprise, on the per--tablet basis, 60-85% by weight of a .beta.-lactam antibiotic, 1-10% by weight of low-substituted hydroxypropylcellulose and/or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5-2% by weight of a binder. Granules to be compressed for tableting are prepared using water or an aqueous solution of ethanol or the like.

Cette invention se rapporte à des comprimés contenant un antibiotique au beta -lactame, qui peuvent facilement être pris tels quels parce qu'ils sont petits, et qui, s'ils doivent être administrés à une personne souffrant de dysphagie, par exemple une personne d'âge avancé, peuvent être pris sous la forme d'une dispersion, puisque, mis dans un verre d'eau, ils se désintègrent rapidement par eux-mêmes. Chacun de ces comprimés contient 60 à 85 % en poids d'antibiotique au beta -lactame, 1 à 10 % en poids d'hydroxypropylcellulose faiblement substituée et/ou de polyvinylpyrrolidone réticulée comme agent de désintégration, et 0,5 à 2 % en poids de liant. Pour produire ces comprimés, les ingrédients qui les composent sont agglomérés en pastille à l'aide d'eau ou d'une solution aqueuse d'éthanol, etc.

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