Beta-lactam antibiotics

Details Beta-lactam antibiotics Beta-lactam antibiotics

C - Chemistry, Metallurgy

07

D

260/100, 260/110

C07D 499/70 (2006.01) C07D 277/20 (2006.01) C07D 499/00 (2006.01) C07D 501/20 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1277977

Abstract: Novel .beta.-lactam antibiotics There is disclosed a novel .beta.-lactam antibiotics rpresented by the formula: Image (I) wherein A is a group represented by the formulae -NHCO-, -NHCONHCO-, -NHCOCH=CH- or Image where R6 is a hydrogen atom or a lower alkyl group; R1 and R2 are independently a hydrogen atom or a protective group; R3 is a hydrogen atom or a methoxy group; X is a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a halogen atom, a lower alkoxy group or a nitro group; n is an integer of 1 or 2; y is a group represented by the formulae: Image provided that a carbon atom which is bonded by a carboxyl group being bonded to nitrogen atom; M is a hydrogen atom, a protective group or an easily hydrolyzable group in a human body; R7 is a hydrogen atom, a methyl group a lower alkoxy- methyl group or a group represented by the formula: -CH2-T where T is an acyloxy group, a carbamoyloxy group, a quaternary ammonium, a substituted or unsub- stituted heterocyclic ring or a formula: -S-R8 where R8 is an acyl group or a substituted or unsubstituted heterocyclic ring, R4 and R5 are each hydrogen atoms or combined with each other to form additional direct bond; Z is a direct bond or a carbonyl group when R4 and R5 are hydrogen atoms, or a formula: -O-B- where the oxygen atom is bonded to nitrogen atom and B is a straight, branched or cyclic alkylene group when R4 and R5 are combined with each other to form additional direct bond, or its pharmaceutically acceptable salt.

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