.beta.-lactam antibiotics, process for their preparation and...

C - Chemistry – Metallurgy – 07 – D

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C07D 501/18 (2006.01) A23K 1/17 (2006.01) A23K 3/02 (2006.01) A61K 31/545 (2006.01) C07D 277/40 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 501/16 (2006.01) C07D 501/24 (2006.01) C07D 501/38 (2006.01) C07D 501/46 (2006.01) C07D 501/56 (2006.01) C09K 15/30 (2006.01)

Patent

CA 1274821

ABSTRACT Novel .beta.-lactam antibiotics of the formula Image in which R1, R2 and R3, which may be identical or different, denote a substituted or unsubstituted alkyl radical or a monocyclic or bicyclic, option- ally substituted, carbocyclic or heterocyclic ring, or R1 represents an optionally substituted alkyl radical or a monocyclic or bicyclic, substituted or unsubstituted, carbocyclic or heterocyclic ring, and R2 and R3, together with the N? atom, form an optionally substituted monocyclic or polycyclic ring which can be saturated or unsaturated and can contain oxygen, sulphur and nitrogen as other hetero atoms, or R1, R2 and R3, together with the N? atom, form a bridged, optionally substituted polycyclic ring which can be saturated or unsaturated and can contain oxygen, sulphur and nitrogen as other hetero atoms, and R4 represents hydrogen or optionally substituted alkyl, aryl or heterocyclyl or hydroxycarbonyl, lower alkoxycarbonyl, halogen, pseudohalogen or a group of the formula Image in which n denotes 0, 1 or 2, and B represents a direct bond, oxygen or a group -?- and A and W, independently of one another, represent hydrogen or optionally substituted alkyl, aryl or heterocyclyl, or together form an optionally sub- stituted carbocyclic or heterocyclic ring.

481749

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