C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/299
C07D 498/04 (2006.01) C07D 503/00 (2006.01)
Patent
CA 1107739
Abstract This invention provides a process for the preparation of a compound of the formula (II): Image (II) or a salt or ester thereof, wherein R2 is a CH=CH2 or CH=CH-CH3 group, which comprises reacting an ester of clavulanic acid with a compound of the formula (III) or (IV): R3 - O - CH = CH2 (III) R3 - O - CH = CH - CH3 (IV) wherein R3 is an alkyl group of up to 6 carbon atoms, in the presence of a mercuric ion catalyst, and thereafter, if desired, de-esterifying the result- ing ester of the compound of the formula (II); and when a compound of the formula (II) or a salt thereof is required, cleaving the corresponding p- nitrobenzyl ester of the compound of the formula (II); and when required converting the resulting compound to a salt of a compound of the formula (II); and when required converting the resulting compound to a pharmaceutically acceptable salt of a compound of the formula (II). The compounds of the formula (II) and salts and esters thereof are novel and have ?-lactamase in- hibitory properties.
308302
Beecham Group Limited
Borden Ladner Gervais Llp
LandOfFree
.beta.-lactam compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .beta.-lactam compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.-lactam compounds will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-538874