.beta.-lactam compounds, preparation and use

Details .beta.-lactam compounds, preparation and use .beta.-lactam compounds, preparation and use

C - Chemistry, Metallurgy

07

D

260/299, 260/278

C07D 498/04 (2006.01) C07C 271/22 (2006.01) C07D 205/085 (2006.01) C07D 503/00 (2006.01)

Patent

CA 1105467

Abstract This invention provides the compounds of the formula (I): Image (I) and salts and esters thereof, wherein R1 is a hydrogen atom or a lower alkyl, aryl or aralkyl group, R2 and R3 are independently hydrogen, aryl, aralkyl, lower alkyl or substituted lower alkyl, or R3 is joined to R1 to form a 4-, 5-, or 6- membered ring or is joined to R2 to form a 5- or 6- membered ring. The compounds have .beta.-lactamase inhibitory properties. The invention also provides a process for their preparation, and pharmaceutical compositions containing them.

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