C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104, 260/114
C07D 499/58 (2006.01) C07C 57/58 (2006.01) C07D 277/20 (2006.01) C07D 277/42 (2006.01) C07D 499/00 (2006.01) C07D 501/20 (2006.01)
Patent
CA 1201431
- 118 - Abstract: .beta.-Lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof There are disclosed a compound having the following formula: Image in which R1 denotes a substituted or unsubstituted thiazolyl radical, a substituted or unsubstituted thiazolylmercapto radical or a substituted or unsubstituted phenyl radical; R2 denotes a halogen atom, a cyano radical, a carbamoyl radical, a lower- alkylmercapto radical or an O-lower-alkylcarbo- xyimidoyl radical; and Y represents a group Image (wherein R3 denotes hydrogen, a salt forming cation or a protective group for a carboxylic acid, and R4 denotes hydrogen or a residue of a nucleophilic compound); process for preparing the same; and an intermediate compound useful for preparing the same. The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also gram-negative bacteria, particularly the resistive gram-negative becteria.
417769
Kobori Takeo
Kojima Etsuko
Kondo Kiyosi
Murakami Yasuo
Sakuma Osamu
Robic Robic & Associes/associates
Sagami Chemical Research Center
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