.beta.-lactam compounds, their preparation and use

Details .beta.-lactam compounds, their preparation and use .beta.-lactam compounds, their preparation and use

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01) C07D 477/20 (2006.01)

Patent

CA 1133907

ABSTRACT The present invention relates to the preparation of compounds of the formula:- Image wherein CO2R1 is a free, salted or esterified carboxyl group, n is 0 or 1, and R2 is hydrogen or an acyl group or a group of the sub-formula (a):- R3O3S (a) wherein R3 is a salting ion or a methyl or ethyl group, with the proviso that when cis R2 is a group of the formula (a), the compound has cis stereochemistry about the .beta.-lactam ring; which have been found to possess anti- bacterial and .beta.-lactamase inhibitory activity.

333979

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