C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/299
C07D 498/04 (2006.01) C07D 203/20 (2006.01) C07D 503/00 (2006.01)
Patent
CA 1121821
Abstract Ethers of Clavulanic Acid, A Process for their Preparation and Pharmaceutical Compositions containing them The compounds of the formula (I): Image (I) and salts and esters thereof (wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a methyl group; and R3 is a hydrogen atom or a COR4, CO2R4 or CONR4R5 group where R4 is an alkyl group of up to 6 carbon atoms or a phenyl or benzyl group and R5 is a hydrogen atom or an alkyl group of up to six carbon atoms) possess .beta.-lactamase inhibitory properties, and give good blood levels and urinary recoveries after administra- tion. The invention further provides a process for the preparation of these compounds, and pharmaceutical compositions containing them.
311405
Beecham Group Limited
Borden Ladner Gervais Llp
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