Beta-lactam derivatives

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/04 (2006.01) A61K 31/395 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01) C07D 501/00 (2006.01)

Patent

CA 1325077

ABSTRACT Title: .beta.-lactam derivatives There are provided compounds of the formula Ia and Ib Image Image (Ia) (Ib) wherein A is hydrogen atom or an organic residue, R1 is halogen atom, or an organic group, R2 is hydrogen or halogen atom, C1-C4 alkyl or alkoxy group R3 is hydrogen atom, C1-C4 alkyl or alkoxy group, benzyl or a methylene group and R4 is an organic residue. Said derivatives (Ia) and (Ib) are endowed with elastase inhibitory activity. A two-step process for their preparation starting from the corresponding 4-carboxy cephen or 3-carboxy penam is also provided.

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