Beta-lactam inhibitors of coa-it

Details Beta-lactam inhibitors of coa-it Beta-lactam inhibitors of coa-it

C - Chemistry, Metallurgy

07

D

C07D 205/085 (2006.01) A61K 31/395 (2006.01) A61K 31/397 (2006.01) A61K 31/4427 (2006.01) A61P 29/00 (2006.01) C07D 205/095 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2288986

This invention relates to a novel method for treating disease or disorders mediated by the lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprising administering to a mammal in need thereof an effective Coenzyme A independent transacylase (CoA-IT) inhibiting amount of a compound of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of formula (I).

L'invention a trait à un nouveau procédé permettant de traiter des maladies ou des troubles dans lesquels interviennent des médiateurs d'inflammation lipidiques, l'acide arachidonique, ses métabolites et/ou le facteur d'activation des plaquettes (PAF). Le procédé comporte l'administration à un mammifère nécessitant un tel traitement d'une quantité efficace, en termes d'action inhibitrice, d'un composé de transacylase indépendante de coenzyme A (CoA-IT) représenté par la formule (I). L'invention a également trait à un procédé permettant de traiter ou de réduire l'inflammation chez un mammifère nécessitant un tel traitement, ce procédé comportant l'administration audit mammifère d'une quantité efficace d'un composé ou d'une composition représenté(e) par la formule (I).

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