.beta.-lactamase inhibiting 2-.beta.-substituted-2-.alpha.-...

Details .beta.-lactamase inhibiting 2-.beta.-substituted-2-.alpha.-... .beta.-lactamase inhibiting 2-.beta.-substituted-2-.alpha.-...

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/00 (2006.01)

Patent

CA 1212378

BETA-LACTAMASE INHIBITING 2-BETA-SUBSTITUTED- 2-ALPHA-METHYL-(5R)PENAM-3-ALPHA-CARBOXYLIC ACID 1,1-DIOXIDES AND INTERMEDIATES THEREFOR Abstract Beta-lactamase inhibiting 2-beta-substituted-2- alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1.1- dioxides and esters thereof, wherein the 2-beta-sub- stituent is cyano, acetyl, alkoxycarbonyl, omega- hydroxyalkoxycarbonyl, carbalkoxymethoxycarbonyl or dialkylaminocarbonyl; intermediates therefor wherein the 2-beta-substituent is carboxy, chlorocarbonyl or aminocarbonyl; methods for their preparation and use as beta-lactamase inhibitors.

411274

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