.beta.-lactams

Details .beta.-lactams .beta.-lactams

C - Chemistry, Metallurgy

07

D

260/228, 260/306

C07D 205/08 (2006.01) C07D 205/085 (2006.01) C07D 277/40 (2006.01) C07D 317/28 (2006.01) C07D 317/72 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 493/14 (2006.01)

Patent

CA 1262128

Abstract optically uniform .beta.-lactams of the general formulae Image Image wherein Z represents a readily cleavable acyl group, R1 represents amino or a group convertible into amino, R2 represents hydrogen or a readily cleavable protecting group and R3 and R4 each represent a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R1 represents readily cleavable acylamino when R2 represents hydrogen, and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active .beta.- -lactams as well as novel intermediates usable in their manufacture.

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