A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4436 (2006.01) A61K 31/00 (2006.01) A61K 31/397 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2289705
This invention relates to a method of treating or reducing cell proliferation in a mammal in need thereof, which comprises administering to said mammal an effective CoA-independent transacylase (CoA-IT) inhibiting amount of a compound of formula (I), wherein the variables of Y, X, m, R3, R4, R10, R20, R5, R6 and R7 are defined in the specification. Figure 3 demonstrates the ability of SB216754, ((3S,4R)-4-(isobutenyloxy)-3- triphenylmethylamino)azetidin-2-one) to decrease the viability of HL-60 cells.
L'invention a trait à un procédé permettant de traiter ou de réduire une prolifération cellulaire chez un mammifère nécessitant un tel traitement, ce procédé comportant l'administration audit mammifère d'une quantité efficace, en termes d'action inhibitrice, d'un composé de transacylase indépendante de coenzyme A (CoA-IT) représenté par la formule (I), ou d'un de ses sels pharmaceutiquement acceptable. Dans la formule, les variables Y, X, m, R¿3?, R¿4?, R¿10?, R¿20?, R¿5?, R¿6? et R¿7? sont telles que définies dans la description. La Fig. 3 montre la capacité de SB 216754, ((3S, 4R)-4-(isobutényloxy)-3-triphénylméthylamino)azétidine-2-one) à réduire la viabilité de cellules HL-60.
Chilton Floyd Harold III
Winkler James David
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
Wake Forest University
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