Beta-lactones as antibacterial agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 305/12 (2006.01) A61K 31/365 (2006.01) A61L 2/16 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) C07D 305/14 (2006.01)

Patent

CA 2716868

The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of in-fections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram- positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.

La présente invention concerne des composés de bêta-lactones spécifiques et leurs compositions pour le traitement d'infections, telles que, par exemple, des infections par des bactéries ou des infections par des protozoaires, en particulier des infections par des bactéries Gram positif et/ou des bactéries Gram négatif et des maladies infectieuses provoquées par ou associées à des bactéries Gram positif et/ou Gram négatif, et la modulation de la virulence des bactéries Gram positif et/ou Gram négatif ou des protozoaires par des composés de bêta-lactones spécifiques. L'invention concerne en outre l'utilisation des composés ou des compositions dans la prévention ou l'élimination des biofilms.

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