Beta-like glycoprotein hormone polypeptide and heterodimer

Details Beta-like glycoprotein hormone polypeptide and heterodimer Beta-like glycoprotein hormone polypeptide and heterodimer

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) C07K 14/575 (2006.01) C07K 14/59 (2006.01) C07K 16/26 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2403800

Novel .beta.10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing .beta.10 polypeptides and heterodimeric forms thereof, specifically .alpha.2/.beta.10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with .beta.10 polypeptides and .alpha.2/.beta.10 heterodimers or their respective binding agents.

L'invention concerne de nouveaux polypeptides .beta.10 et leurs hétérodimères, ainsi que les molécules d'acides nucléiques les codant. Elle concerne également des vecteurs, des cellules hôtes, des agents de liaison sélectifs et des procédés servant à préparer ces polypeptides de .beta.10 et leur forme hétérodimère, en particulier .alpha.2/.beta.10. Elle concerne également des procédés de traitement, de diagnostic, d'amélioration ou de prévention de maladies au moyen de ces polypeptides .beta.10 et des hétérodimères .alpha.2/.beta.10 ou de leurs agents de liaison respectifs.

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