Beta retinoic acid response elements compositions and assays

Details Beta retinoic acid response elements compositions and assays Beta retinoic acid response elements compositions and assays

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2072644

2072644 9107488 PCTABS00005 The present invention provides transcriptional control regions, expression vectors comprising said regions, mammalian cells transformed to transcribe and express genes from said vectors, and various methods of assaying compounds for hormone agonist or antagonist activity, all based on discovery of response elements of the .beta.-retinoic acid receptor and of the activation of said response elements in all mammalian cells without need to transform the cells to express the receptor independently of endogenous expression thereof.

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