.beta.-secretase enzyme compositions and methods

Details .beta.-secretase enzyme compositions and methods .beta.-secretase enzyme compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/16 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2359785

Disclosed are various forms of an active, isolated .beta.-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (.beta.- APPwt and .beta.-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate .beta.-secretase. Inhibitors of .beta.-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

L'invention concerne différents types d'enzyme bêta-sécrétase active isolée, sous forme purifiée et de recombinaison, intervenant dans la production des éléments de plaque amyloïde qui s'accumulent dans le cerveau des personnes souffrant de la maladie d'Alzheimer. L'invention concerne en outre des cellules de recombinaison qui produisent l'enzyme en question, séparément ou en combinaison avec certains des ses substrats naturels (.beta.-APPwt et .beta.-APPsw), et elle concerne aussi des anticorps vis-à-vis de ces protéines. Les compositions considérées sont utiles dans les procédés relatifs à la sélection des composés qui modulent la bêta-sécrétase. Les inhibiteurs de la bêta-sécrétase interviennent comme éléments thérapeutiques dans le traitement des maladies neurodégénératives comme la maladie d'Alzheimer.

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