Beta-secretase substrates and uses thereof

Details Beta-secretase substrates and uses thereof Beta-secretase substrates and uses thereof

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/08 (2006.01) C07K 5/107 (2006.01) C07K 5/11 (2006.01) C07K 5/113 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/06 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2448142

The present invention provides synthetic .beta.-secretase peptide substrates useful in various assays for measuring .beta.-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.

L'invention concerne des substrats peptidiques de .beta.-secrétase synthétiques utilisés dans différents essais servant à mesurer l'activité de la .beta.-secrétase. L'invention concerne également des anticorps qui reconnaissent ces substrats synthétiques ainsi que des utilisations de ces anticorps dans différents essais. Les substrats peptidiques décrits sont hydrolysés à des vitesses sensiblement supérieures à celle qui a été observée chez le mutant <=suédois >= de l'APP, duquel les séquences de substrat sont dérivées.

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