C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 38/04 (2006.01) C07D 209/48 (2006.01) C07D 487/04 (2006.01) C07K 5/078 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2319766
.beta.-sheet mimetics and methods relating to the same are disclosed. The .beta.-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a .beta.- sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.
L'invention concerne des imitateurs de .beta.-feuillets et de procédés associés. Les imitateurs de .beta.-feuillets sont utiles en tant qu'inhibiteurs de protéase et de kinase, ainsi que comme inhibiteurs de facteurs de transcription et d'interaction de liaison protéine-protéine. Les procédés consistent à administrer un imitateur de .beta.-feuillets ou à utiliser celui-ci pour fabriquer un médicament pour le traitement d'une grande variété de pathologies associées à la protéase, à la kinase, au facteur de transcription et/ou à l'interaction de liaison protéine-protéine ciblés.
Kahn Michael S.
Mathew Jessymol
Mcmillan Michael K.
Qaber Maher N.
Tulinsky John E.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Molecumetics Ltd.
Myriad Genetics Inc.
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