Beta-substituted alpha-halo-acrylonitriles antimicrobial agents

A - Human Necessities – 01 – N

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A01N 37/34 (2006.01) A01N 37/36 (2006.01) A01N 39/00 (2006.01) A01N 43/78 (2006.01) A01N 47/14 (2006.01) C07C 333/20 (2006.01) C07D 277/36 (2006.01) C07D 277/74 (2006.01)

Patent

CA 1338896

Useful as antimicrobial agents are .beta.-substituted .alpha.-halo-acrylonitriles of the formula Image wherein X represents chlorine, bromine or iodine and R represents a lower alkyl, aryl, aralkyl, heterocyclyl, or thiocarbonyl group. These compounds may be incorporated in aqueous compositions subject to spoilage by microbial growth to control such growth. All the compounds apart from .alpha.-bromo-.beta.-methylthio-acrylonitrile and the corresponding .beta.-phenylthio compound are novel and may be produced (in a final reaction step) by nucleophilic-type displacement of the .beta.-halogen atom X of an appropriate .alpha.,.beta.-dihalo- acrylonitrile X-CH=CX(CN) (IV) using a sulfur anion RS- derived from the appropriate mercaptan RSH.

591984

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