C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/44 (2006.01) A61K 31/16 (2006.01) A61K 31/415 (2006.01) C07D 233/72 (2006.01)
Patent
CA 2266368
The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, -(CH2)h-aryl or -(CH2)h-het; R2 is C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, -(CH2)h-C3-8 cycloalkenyl, -(CH2)h-aryl, -(CH2)h-het, -(CH2)h-Q, -(CH2)i-X-R4 or - (CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
L'invention concerne un composé représenté par la formule (I), ou des sels pharmaceutiquement acceptables de celui-ci, dans laquelle R¿1? est C¿4-12? alkyle, C¿4-12? alcényle, C¿4-12? alcynyle, -(CH¿2?)¿h?-C¿3-8? cycloalkyle, -(CH¿2?)¿h?-aryle ou -(CH¿2?)¿h?-het; R¿2? est C¿1-12? alkyle, C¿2-12? alcényle, C¿2-12? alcynyle, -(CH¿2?)¿h?-C¿3-8? cycloalkyle, -(CH¿2?)¿h?-C¿3-8? cycloalcényle, -(CH¿2?)¿h?-aryle, -(CH¿2?)¿h?-het, -(CH¿2?)¿h?-Q, (CH¿2?)¿i?-X-R¿4? ou -(CH¿2?)¿i?CHR¿5?R¿6?. Lesdits composés sont des inhibiteurs de métalloprotéinases matricielles intervenant dans la dégradation des tissus.
Harper Donald E.
Warpehoski Martha A.
Macrae & Co.
Pharmacia & Upjohn Company
LandOfFree
.beta.-sulfonyl hydroxamic acids as matrix... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .beta.-sulfonyl hydroxamic acids as matrix..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .beta.-sulfonyl hydroxamic acids as matrix... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1392298