C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/58 (2006.01) A61K 31/198 (2006.01) A61P 25/00 (2006.01) C07C 323/61 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2421990
The invention relates to .beta.-thio-.alpha.-amino acids of formula I (see formula I) and uses of .beta.-thio-.alpha.-amino acids of formula I, for treatment of one or more of pain, epilepsy and migraine; for treatment of hyperalgesia, allodynia, inflammatory pain or post-operative pain; for treatment of hot flushes, post-menopausal symptoms, amyotropic lateral sclerosis (ALS), reflex sympathetic dystrophy (RSD), spastic paralysis, restless leg syndrome, acquired nystagmus, a psychiatric disorder, a neuropathological disorder, painful diabetic neuropathy, symptoms and pain due to multiple sclerosis, symptoms and pain due to Parkinson's disease, a neurodegenerative disease, gastrointestinal lesions, erythromelalgic pain, post-poliomyelitic pain, trigeminal neuralgia, or post-herpes neuralgia; or that is an anticonvulsant, analgesic or anxiolytic. The invention also relates to a process for producing the .beta.-thio-.alpha.-amino acids of formula of the invention.
L'invention concerne des acides ss-thio- alpha -aminés de formule générale (I), dans laquelle R<1>, R<2> et R<3> ont la signification indiquée dans la description, leur procédé de production, un médicament contenant ces composés et l'utilisation d'acides thio-aminés pour la production de médicaments.
Chizh Boris
Enders Dieter
Gaube Gero
Gerlach Matthias
Haurand Michael
Fetherstonhaugh & Co.
Gruenenthal Gmbh
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