Beta2-adrenoceptor agonists

Details Beta2-adrenoceptor agonists Beta2-adrenoceptor agonists

C - Chemistry, Metallurgy

07

D

C07D 215/26 (2006.01) A61K 31/395 (2006.01) A61P 43/00 (2006.01) C07C 215/80 (2006.01) C07C 233/43 (2006.01) C07C 311/08 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2375810

Compounds of formula (I) in free or salt or solvate form, where Ar is a group of formula (II) Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases. The compounds of formula (I) in free, salt or solvate form, have .beta.2-adrenoreceptor agonist activity.

L'invention concerne des composés de la formule (I) sous forme libre, saline ou de solvates. Dans ladite formule, Ar est un groupe de la formule (II), Y est carbone ou azote et R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, X, n, p, q et r sont tels que définis dans le mémorandum descriptif. L'invention concerne également la préparation de ces composés et leur utilisation comme produits pharmaceutiques, notamment pour le traitement de maladies respiratoires obstructives ou inflammatoires. Les composés de la formule (I), sous leur forme libre, saline ou de solvates, présentent une activité d'agoniste du récepteur BETA 2-adrénergique.

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