Bh3 interacting domain death agonist

Details Bh3 interacting domain death agonist Bh3 interacting domain death agonist

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 5/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2264578

A novel death agonist, BID, which contains only a BH3 domain but not the BH1, BH2, BH4 or membrane anchoring domains found in related BCL-2 family members is provided along with derivatives of BID, bid polynucleotides and derivatives thereof and compositions and uses therefor.

L'invention concerne un nouvel agoniste de mort, BID, lequel ne ocontient qu'un domaine BH3 et non les domaines BH1, BH2, BH4 ou de fixation sur membrane rencontrés dans les membres apparentés de la famille BCL-2, ainsi que des dérivés BID, ces polynucléotides bid et dérivés de ceux-ci ainsi que des compositions les contenant et leurs utilisations.

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