Bi- and tricyclic indazole-substituted 1,4-dihydropyridine...

Details Bi- and tricyclic indazole-substituted 1,4-dihydropyridine... Bi- and tricyclic indazole-substituted 1,4-dihydropyridine...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/4355 (2006.01) A61K 31/436 (2006.01) A61K 31/437 (2006.01) A61K 31/438 (2006.01) A61K 31/4427 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 491/052 (2006.01) C07D 491/147 (2006.01) C07D 491/153 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2752603

This invention relates to novel bi- and tricyclic indazole-substituted 1,4- dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.

Cette invention porte sur des nouveaux dérivés de 1,4-dihydropyrimidine substitués par indazole bi- et tricycliques ayant une activité inhibitrice de protéine tyrosine kinase, sur un procédé pour leur fabrication et sur leur utilisation pour le traitement de maladies à médiation par c-Met ou d'états à médiation par c-Met, en particulier le cancer et autres troubles prolifératifs.

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